257 Plasmacytoid dendritic cell-derived type I interferon drives flares of rosacea
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چکیده
منابع مشابه
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following enc...
متن کاملIMMUNOBIOLOGY Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon
1Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland; 2Unidad de Investigación Médica en Inmunoquı́mica, Hospital de Especialidades, Mexico City, Mexico; 3Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Germany; 4Institute of Experimental Immunology, University Hospital, Zurich, Switzerland; 5Department of Host Defens...
متن کاملControl of coronavirus infection through plasmacytoid dendritic cell-derived type I interferon Running title: Plasmacytoid dendritic cell-dependent control of coronavirus infection
Research Department, Kantonal Hospital St. Gallen, St. Gallen, Switzerland, Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Mexico City, Mexico, Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D-79008 Freiburg, Germany, Institute of Experimental Immunology, University Hospital, Zurich, Switzerland, Department of Host D...
متن کاملRegulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells
Mitochondrial reactive oxygen species (mtROS) generated continuously under physiological conditions have recently emerged as critical players in the regulation of immune signaling pathways. In this study we have investigated the regulation of antiviral signaling by increased mtROS production in plasmacytoid dendritic cells (pDCs), which, as major producers of type I interferons (IFN), are the k...
متن کاملPlasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.
There is a high demand for the development of adjuvants that induce cytotoxic T lymphocytes, which are crucial for the elimination of intracellular pathogens and tumor cells. Toll-like receptor (TLR) agonists are prime candidates to fulfill this role because they induce innate immune activation and promote adaptive immune responses. The successful application of the TLR7 agonist R837 for treatm...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.277